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October 1, 1976Acta Physiologica Scandinavica

Plasma Renin Activity Following Central Infusion of Angiotensin II and Altered CSF Sodium Concentration in the Conscious Goat

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Population

Conscious hydrated and non-hydrated goats

Design

Preclinical

Authors

LELea ErikssonUniversity of HelsinkiFFFrej FyhrquistGeneral / Preventive / Lipids

Discussion

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Overview

Central angiotensin II and CSF sodium modulate renin in animals; leaves open human relevance and clinical translation.

Structured PICO

P
Population
Conscious hydrated and non-hydrated goats
I
Intervention
Infusion of angiotensin II (0.5 to 1 mug), hypertonic NaCl, or isotonic fructose solution into the lateral cerebral ventricle
O
Outcome
Plasma renin activity (PRA)surrogate

Central administration of angiotensin II and changes in CSF sodium concentration modulate renal renin release via the central nervous system.

Cite This Study

Eriksson et al. (1976) studied this question.

synapsesocial.com/papers/6a8932017c664faad1127127https://doi.org/10.1111/j.1748-1716.1976.tb00238.x
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  4. 4ANGIOTENSIN II PLASMA LEVELS IN HYPERTENSIVE PATIENTS1972 · 14 citations
  5. 5The Renin-Angiotensin System1974 · 310 citations