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September 1, 1975Endocrinology

The Effects of Intracerebroventricular Administration of Renin on Drinking and Blood Pressure1

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Key result

Intracerebroventricular administration of renin in dogs increased systolic blood pressure from 152 to 168 mm Hg (P<0.001) and stimulated drinking, effects abolished by an angiotensin II antagonist.

Why the study?

Does intracerebroventricular administration of renin increase drinking and blood pressure in dogs?

Population

Dogs

Comparison

Intracerebroventricular administration of hog or… vs Intraventricular saralasin acetate preceding…

Design

Preclinical

Follow-up

Up to 3 hours

Authors

IRIan A. ReidUniversity of Nebraska at OmahaDRD. J. RamsayCentennial College

Discussion

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Implication

Supports brain RAS existence; leaves open its role in human BP regulation.

Key Points

  • The research aims to determine the presence of angiotensinogen in cerebrospinal fluid and explore how renin affects drinking and blood pressure.
  • Measured angiotensinogen concentration in cerebrospinal fluid from 15 dogs.
  • Administered intraventricular renin in 8 dogs to assess drinking response and blood pressure changes.
  • Used saralasin acetate to evaluate the mediation through angiotensin II.
  • Intraventricular renin increased drinking volume to 485 +/- 84 ml in 15 minutes.
  • Systolic blood pressure rose from 152 +/- 10 to 168 +/- 10 mm Hg (P < 0.001).
  • Diastolic pressure increased from 101 +/- 8 to 116 +/- 7 mm Hg (P < 0.001), with responses blocked by saralasin.

Structured PICO

Does intracerebroventricular administration of renin increase drinking and blood pressure in dogs?

P
Population
15 dogs evaluated for the physiological effects of intracerebroventricular administration of renin on drinking behavior and blood pressure.
I
Intervention
Intracerebroventricular administration of hog or dog renin (0.05-0.25 Goldblatt units)
C
Comparator
Intraventricular saralasin acetate (a specific antagonist of angiotensin II) preceding renin administration
O
Outcome
Drinking volume and blood pressure (systolic and diastolic)surrogate

Main Result

p-value: p=<0.001

Centrally administered renin increases drinking and blood pressure in dogs, and these effects are mediated via the formation of angiotensin II.

Cite This Study

Reid et al. (1975) studied this question. Intracerebroventricular renin vs. Baseline and saralasin acetate was evaluated on Systolic blood pressure and drinking volume (p=<0.001). Intracerebroventricular administration of renin in dogs increased systolic blood pressure from 152 to 168 mm Hg (P<0.001) and stimulated drinking, effects abolished by an angiotensin II antagonist.

synapsesocial.com/papers/6a6bcc85285b5e3c3db3c40bhttps://doi.org/10.1210/endo-97-3-536
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Drinking and haemodynamic changes induced in the dog by intracranial injection of components of the renin‐angiotensin system.1978 · 65 citations
  2. 2Hemodynamic Effects of the Intraventricular Administration of Angiotensin II and Renin in Awake Dogs1985
  3. 3Hemodynamic Effects of Chronic Intraventricular Administration of Renin in Awake Dogs1984 · 1 citations
  4. 4Brain Angiotensin II Stimulates Release of Pituitary Hormones, Plasma Catecholamines and Increases Blood Pressure in Dogs1980 · 29 citations
  5. 5Angiotensin II Concentration in Cerebrospinal Fluid after Intraventricular Injection of Angiotensinogen or Renin*1978 · 26 citations