October 1, 1978Endocrinology

Angiotensin II Concentration in Cerebrospinal Fluid after Intraventricular Injection of Angiotensinogen or Renin*

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Population

Anesthetized dogs

Comparison

Intraventricular injection of partially purified… vs Baseline (before injection)

Design

Preclinical

Follow-up

Various intervals after injection

Authors

IRIan A. ReidUniversity of Nebraska at Omaha BMBarbara MoffatSimon Fraser University

Discussion

Member takes

Implication

Questions functional brain renin activity in this model; leaves open central angiotensin II generation mechanisms.

Structured PICO

Population

Anesthetized dogs

Intervention

Intraventricular injection of partially purified renin substrate (angiotensinogen) or renin into the third cerebral ventricle

Comparator

Baseline (before injection)

Outcome

Angiotensin II concentration in cerebrospinal fluid (CSF)surrogate

The study fails to demonstrate in vivo renin activity in the brain, as exogenous angiotensinogen did not lead to central angiotensin II formation, unlike exogenous renin.

Cite This Study

Reid et al. (1978) studied this question.

synapsesocial.com/papers/6a8931fd6ef699e80f1ff5f1 https://doi.org/10.1210/endo-103-4-1494

View Full Paper

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Angiotensin II Concentration in Cerebrospinal Fluid after Intraventricular Injection of Angiotensinogen or Renin*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Concentration in Cerebrospinal Fluid after Intraventricular Injection of Angiotensinogen or Renin*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider