Why the study?
Does intracerebroventricular renin administration increase blood pressure and stimulate hormone release in conscious dogs?
Population
Conscious dogs on normal or sodium-deficient diets
Comparison
Intracerebroventricular injection of 0.5 unit of… vs Normal vs sodium-deficient diets; captopril…
Design
Preclinical
Authors
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Supports central renin effects on BP and hormones in dogs; hypothesis-generating for brain RAS in hypertension, no practice implications.
Does intracerebroventricular renin administration increase blood pressure and stimulate hormone release in conscious dogs?
Endogenous brain angiotensin II regulates blood pressure centrally by stimulating the release of antidiuretic hormone, adrenocorticotrophic hormone, and catecholamines.
Schölkens et al. (1980) studied this question.
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