What question did this study set out to answer?

To determine whether the central nervous system actions of angiotensin II—including blood pressure regulation, thirst stimulation, and endocrine responses—occur within normal physiological concentrations.

July 1, 1982AJP Regulatory Integrative and Comparative Physiology

Analysis of the actions of angiotensin on the central nervous system of conscious dogs

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Why the study?

Does Angiotensin II infusion alter blood pressure, drinking behavior, and hormone secretion in conscious dogs?

Population

Conscious dogs with small catheters chronically implanted in both carotid and both vertebral arteries

Design

Preclinical

Authors

IRI. A. ReidThe University of Sydney VBVirginia L. BrooksOregon Health & Science University CRColin D. RudolphAstraZeneca (United Kingdom)

Discussion

Member takes

Implication

Animal data on angiotensin II central actions warrant caution in extrapolation; extends basic mechanisms but leaves open human applicability.

Key Points

To determine whether the central nervous system actions of angiotensin II—including blood pressure regulation, thirst stimulation, and endocrine responses—occur within normal physiological concentrations.
Conscious dogs chronically instrumented with bilateral carotid and vertebral artery catheters received infusions of angiotensin II at doses of 0.1, 0.33, 1.0, and 2.5 ng·kg⁻¹·min⁻¹.
A parallel group received intravenous angiotensin II infusions at doses of 2, 5, 10, and 20 ng·kg⁻¹·min⁻¹ to evaluate systemic versus central responses.
Intravertebral infusions produced dose-dependent blood pressure increases accompanied by heart rate elevation, whereas intracarotid infusions raised blood pressure without altering heart rate.
Both intracarotid and intravertebral angiotensin II suppressed plasma renin activity and stimulated drinking behavior at peptide concentrations within the physiological range.
Increases in vasopressin, corticotropin, and corticosteroid secretion occurred only at the highest administered doses across arterial and intravenous routes, indicating a requirement for supraphysiological levels.

Structured PICO

Does Angiotensin II infusion alter blood pressure, drinking behavior, and hormone secretion in conscious dogs?

Population

Conscious dogs with small catheters chronically implanted in both carotid and both vertebral arteries

Intervention

Angiotensin II (ANG II) infused into both carotid or both vertebral arteries in doses of 0.1, 0.33, 1.0, and 2.5 ng.kg-1.min-1, or intravenously in doses of 2, 5, 10, and 20 ng.kg-1.min-1

Outcome

Changes in blood pressure, heart rate, drinking behavior, secretion of vasopressin, ACTH, corticosteroids, and plasma renin activity (PRA)surrogate

Angiotensin II exerts central cardiovascular and dipsogenic effects at physiological concentrations, while its effects on vasopressin and ACTH secretion require supraphysiological levels.

Cite This Study

Reid et al. (1982) studied this question.

synapsesocial.com/papers/6a848874c7e37ebe3168e5a2 https://doi.org/10.1152/ajpregu.1982.243.1.r82

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Implication

Animal data on angiotensin II central actions warrant caution in extrapolation; extends basic mechanisms but leaves open human applicability.

Analysis of the actions of angiotensin on the central nervous system of conscious dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Analysis of the actions of angiotensin on the central nervous system of conscious dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider