May 1, 1979HypertensionOpen Access

Circulatory effects of chronic administration of angiotensin II into the cerebrolateral ventricles of dogs. Studies on the development of an experimental model of hypertension.

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Why the study?

Does intraventricular administration of angiotensin II elevate arterial pressure in mongrel dogs?

Population

Mongrel dogs

Design

Preclinical

Follow-up

2 weeks

Authors

BJBhagavan S. JandhyalaUniversity of Houston MLM F LokhandwalaSanta Clara University PNP NandiwadaTulane University

Discussion

Member takes

Implication

Should not alter clinical practice; hypothesis-generating for central angiotensin II in experimental hypertension models.

Structured PICO

Does intraventricular administration of angiotensin II elevate arterial pressure in mongrel dogs?

Population

Mongrel dogs

Intervention

Intraventricular administration of angiotensin II, 1 fig, twice a day for 2 weeks, together with saline as the drinking fluid during the second week

Outcome

Arterial pressuresurrogate

Chronic cerebrolateral ventricular administration of angiotensin II in dogs induces vascular alterations conducive to the development of high blood pressure, providing an experimental model for hypertension.

Cite This Study

Jandhyala et al. (1979) studied this question.

synapsesocial.com/papers/6a8932017c664faad1127125 https://doi.org/10.1161/01.hyp.1.3.219

Topics

Hypertension management

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Circulatory effects of chronic administration of angiotensin II into the cerebrolateral ventricles of dogs. Studies on the development of an experimental model of hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Circulatory effects of chronic administration of angiotensin II into the cerebrolateral ventricles of dogs. Studies on the development of an experimental model of hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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