Why the study?
Does chronic intraventricular administration of renin produce physiological and/or pathological effects in awake dogs, and is an increase in daily sodium intake necessary?
Population
awake instrumented dogs
Design
Preclinical
Authors
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Hypothesis-generating in dogs; does not support clinical changes in sodium intake or renin pathways.
Does chronic intraventricular administration of renin produce physiological and/or pathological effects in awake dogs, and is an increase in daily sodium intake necessary?
This preclinical study investigates whether chronic intraventricular renin administration in dogs requires increased sodium intake to produce hemodynamic effects.
Chelly et al. (1984) studied this question.
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