Hypertensive and renal effects of chronic low level intrarenal angiotensin infusion in the dog.

Thomas E. Lohmeier; Allen W. Cowley

doi:10.1161/01.res.44.2.154

February 1, 1979Circulation ResearchOpen Access

Hypertensive and renal effects of chronic low level intrarenal angiotensin infusion in the dog.

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Why the study?

Does intrarenal angiotensin II infusion produce chronic hypertension and sodium retention in dogs with unilateral nephrectomy?

Key Points

To determine whether the direct intrarenal sodium-retaining actions of low-dose angiotensin II can cause chronic hypertension.
Infused angiotensin II directly into the renal artery of 5 uninephrectomized dogs at 1 ng/kg/min for 10 days.
Administered intravenous angiotensin II infusions (0.5 ng/kg/min) to 4 uninephrectomized control dogs for 10 days.
Continuously monitored 24-hour mean arterial pressure alongside GFR, effective renal plasma flow, and urinary sodium excretion.
Intrarenal infusion immediately reduced GFR, ERPF, and urinary sodium excretion; mean arterial pressure rose by 9 mm Hg on day 2 and peaked at +15 mm Hg by day 10.
Intravenous infusion caused no initial sodium retention or hypertension during the first 48 hours, producing a smaller pressure increase of 7 mm Hg over days 3 to 10.
Stopping intrarenal infusion on day 10 caused rapid rebound increases in GFR, ERPF, and sodium excretion, returning arterial pressure to baseline within hours.

Structured PICO

Does intrarenal angiotensin II infusion produce chronic hypertension and sodium retention in dogs with unilateral nephrectomy?

P

Population

9 dogs with unilateral nephrectomy

I

Intervention

Angiotensin II infused directly into the renal artery at 1 ng/kg per min for 10 days

C

Comparator

Angiotensin II infused intravenously at 0.5 ng/kg per min for 10 days

O

Outcome

Mean arterial pressure (MAP), glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and urinary sodium and potassium excretionsurrogate

Intrarenal angiotensin II infusion produces chronic sodium retention and sustained elevation in mean arterial pressure in dogs, demonstrating its direct renal role in hypertension.

Implication

Supports direct renal angiotensin II effects in canine hypertension models; leaves open translation to human disease mechanisms.

Abstract

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Discussion

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Cite This Study

Lohmeier et al. (1979) studied this question.

synapsesocial.com/papers/6a72bbfbe36a167817e40aa0 https://doi.org/10.1161/01.res.44.2.154

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Hypertensive and renal effects of chronic low level intrarenal angiotensin infusion in the dog.

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Hypertensive and renal effects of chronic low level intrarenal angiotensin infusion in the dog.

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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