Why the study?
Does intrarenal infusion of Angiotensin II alter renal sodium and water excretion in uninephrectomized conscious dogs?
Does intrarenal infusion of Angiotensin II alter renal sodium and water excretion in uninephrectomized conscious dogs?
Low-dose intrarenal angiotensin II directly induces dose-dependent antinatriuresis and antidiuresis, with renal escape occurring by 48 hours independent of endogenous renin-angiotensin suppression.
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Hypothesis-generating for direct intrarenal AII actions in dogs; leaves open human translation and therapeutic relevance.
Siragy et al. (1987) studied this question.
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