What does this research mean for the field?

A low dose of Angiotensin II preferentially constricts the efferent arteriole, but this preferential effect disappears when prostanoid synthesis is inhibited, indicating that vasodilatory prostaglandins protect the afferent arteriole from constriction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1986Kidney & Blood Pressure Research

Angiotensin II: Preferential Efferent Constriction?

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Structured PICO

Population

Dogs with maximal suppression of endogenous angiotensin II production due to a high-salt diet and converting enzyme inhibition (SQ 14,225, 15 micrograms/kg/min i.v.)

Intervention

Infusion of a subpressor dose of angiotensin II (1 ng/kg/min) alone or with concomitant infusion of indomethacin (1 mg/kg/min) or aspirin (5 mg/kg/min)

Comparator

Contralateral kidney function / baseline state

Outcome

Renal blood flow (RBF), glomerular filtration rate (GFR), and filtration fraction (FF)surrogate

A subpressor dose of angiotensin II causes preferential efferent arteriole constriction, an effect mediated by the protective vasodilation of prostaglandins on the afferent arteriole.

Discussion

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Implication

Supports prostaglandin-mediated afferent protection in Ang II models; leaves open translation to human renal hemodynamics.

Cite This Study

Heller et al. (1986) studied this question.

synapsesocial.com/papers/6a1b36ed5853c704fce590f2 https://doi.org/10.1159/000173101

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Angiotensin II: Preferential Efferent Constriction?

Structured PICO

Discussion

Implication

Cite This Study

Angiotensin II: Preferential Efferent Constriction?

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider