Why the study?
Does [1-sarcosine-8-alanine]angiotensin II impair autoregulation of GFR and RBF in an isolated dog kidney model?
Population
Isolated dog kidney model (non-renin-depleted and renin-depleted)
Comparison
[1-sarcosine-8-alanine]angiotensin II infused… vs Isolated kidney not infused with the antagonist
Design
Preclinical
Authors
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Does not implicate angiotensin II in renal autoregulation; leaves open mechanisms in intact models.
Does [1-sarcosine-8-alanine]angiotensin II impair autoregulation of GFR and RBF in an isolated dog kidney model?
The angiotensin II antagonist [1-sarcosine-8-alanine]angiotensin II does not impair renal autoregulation of GFR and RBF, suggesting the renin-angiotensin system does not mediate this autoregulation.
Kaloyanides et al. (1976) studied this question.
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