Why the study?
Do 1-Sar, 8-Ala angiotensin II and 1-Sar, 8-Ile angiotensin II modify the regulation of glomerular filtration rate in cats?
Population
Anaesthetized unilaterally nephrectomized cats
Comparison
1-Sar, 8-Ala angiotensin II and 1-Sar, 8-Ile… vs Absence of drug (control state)
Design
Preclinical
Authors
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Animal data on these analogs warrant no clinical translation; leaves open intrarenal angiotensin II as a GFR regulator in humans.
Do 1-Sar, 8-Ala angiotensin II and 1-Sar, 8-Ile angiotensin II modify the regulation of glomerular filtration rate in cats?
1-Sar, 8-Ile angiotensin II, but not 1-Sar, 8-Ala angiotensin II, modifies the regulation of glomerular filtration rate in cats, suggesting angiotensin II has an important intra-renal site of action.
Edward J. Johns (1980) studied this question.
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