Population
Adult female Sprague-Dawley rats with thermal lesions of the medial basal forebrain
Comparison
Centrally administered angiotensin-II or saralasin vs Baseline levels, sham lesions, or concomitant…
Design
Preclinical
Follow-up
10 min intervals after administration
Authors
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Central angiotensin-II effects on renal sympathetic activity are mediated via medial basal forebrain in animals; extends mechanistic models but leaves open human translation.
Angiotensin-II acts centrally on neurons in the medial basal forebrain to increase renal sympathetic nerve activity and modulate renin release.
L. Bruce Weekley (1991) studied this question.
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