Population
Rats given thermal lesions of the medial basal forebrain or sham surgery, with right kidney vascularly…
Comparison
Intracerebroventricular administration of… vs Pre-injection levels, sham surgery controls, and…
Design
Preclinical
Follow-up
10 min intervals after injection
Authors
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Does not support clinical translation; extends central ANG-II modulation of renal sympathetic activity in animal models.
Centrally administered angiotensin-II modulates renal sympathetic nerve activity and renin secretion via pathways dependent on the medial basal forebrain.
L. Bruce Weekley (1992) studied this question.
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