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September 1, 1984AJP Heart and Circulatory Physiology

Central nervous system action of angiotensin during onset of renal hypertension in awake rats

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Why the study?

Does central nervous system action of angiotensin II contribute to the increase in arterial pressure and vascular resistance during acute unilateral renal artery stenosis in conscious rats?

Population

Conscious rats chronically instrumented with miniaturized Doppler flow probes and an implanted pneumatic…

Comparison

Surgical interruption of the anterior… vs Normotensive controls or animals with intact ANG…

Design

Preclinical

Follow-up

60 min

Authors

JFJames E. FaberUniversity of North Carolina at Chapel HillMBMichael J. BrodyUniversity of the Sciences

Discussion

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Implication

Central ANG II contributes to acute renovascular hypertension in rats; leaves open translation to human renovascular disease and clinical practice.

Structured PICO

Does central nervous system action of angiotensin II contribute to the increase in arterial pressure and vascular resistance during acute unilateral renal artery stenosis in conscious rats?

P
Population
Conscious rats chronically instrumented with miniaturized Doppler flow probes and an implanted pneumatic occluder, subjected to a 50% reduction in unilateral renal flow.
I
Intervention
Surgical interruption of the anterior hypothalamus ANG II pressor pathway or central ANG II receptor blockade with intracerebroventricular (icv) saralasin.
C
Comparator
Normotensive controls or animals with intact ANG II pressor pathways.
O
Outcome
Arterial pressure and regional vascular resistance.surrogate

Activation of the sympathetic nervous system during the early high-renin phase of renal hypertension depends significantly on a central action of angiotensin II, accounting for 40-50% of the pressure increase.

Cite This Study

Faber et al. (1984) studied this question.

synapsesocial.com/papers/6a6f9be835aa2c282ce0f396https://doi.org/10.1152/ajpheart.1984.247.3.h349
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neural contribution to renal hypertension following acute renal artery stenosis in conscious rats.1983 · 42 citations
  2. 2Neurohumoral contributions to chronic angiotensin-induced hypertension1986 · 35 citations
  3. 3RENAL DENERVATION ATTENUATES LONG‐TERM HYPERTENSIVE EFFECTS OF ANGIOTENSIN II IN THE RAT2006 · 34 citations
  4. 4CONTRIBUTION OF THE SYMPATHETIC NERVOUS SYSTEM TO THE CENTRALLY-INDUCED PRESSOR ACTION OF ANGIOTENSIN II IN RATS1982 · 9 citations
  5. 5The Central Effects of the Renin-Angiotensin System1988 · 13 citations