Key result
Acute renal artery stenosis in conscious rats with reduced renin-angiotensin and baroreflex gain elicited substantial increases in arterial pressure (25-30 mm Hg) dependent on afferent renal nerves.
Why the study?
Does afferent renal nerve denervation prevent hypertension following acute renal artery stenosis in conscious rats with reduced baroreflex gain and renin-angiotensin system blockade?
Population
Conscious rats with acute renal artery stenosis, with or without sinoaortic denervation
Comparison
Acute renal artery stenosis with captopril… vs Sham sinoaortic denervation; pre-denervation state
Design
Preclinical
Follow-up
60 minutes
Authors
Loading...
Afferent renal nerves may drive hypertension in acute stenosis with impaired baroreflexes; hypothesis-generating for denervation in humans.
Does afferent renal nerve denervation prevent hypertension following acute renal artery stenosis in conscious rats with reduced baroreflex gain and renin-angiotensin system blockade?
Acute reductions in renal blood flow activate an afferent renal nerve-dependent hypertensive response that becomes prominent when baroreflexes and the renin-angiotensin system are impaired.
Faber et al. (1985) studied Acute renal artery stenosis and hypertension. Acute renal artery stenosis (50% reduction in renal blood flow) vs. Denervation of the stenotic kidney was evaluated on Arterial pressure and regional resistance. Acute renal artery stenosis in conscious rats with reduced renin-angiotensin and baroreflex gain elicited substantial increases in arterial pressure (25-30 mm Hg) dependent on afferent renal nerves.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: