What question did this study set out to answer?

To review the pathophysiological contributions of efferent and afferent renal sympathetic nerves to the development and maintenance of hypertension in experimental animal models and humans.

July 1, 1983AJP Renal Physiology

Renal nerves in the pathogenesis of hypertension in experimental animals and humans

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Why the study?

Does renal denervation prevent or attenuate hypertension in experimental animals and humans?

Key Points

To review the pathophysiological contributions of efferent and afferent renal sympathetic nerves to the development and maintenance of hypertension in experimental animal models and humans.
Synthesized findings from renal denervation studies in spontaneously hypertensive rats (Okamoto and New Zealand), DOCA-salt-treated rats, Goldblatt hypertension models (1K1C and 2K1C), and canine aortic coarctation models.
Evaluated the actions of efferent nerves on renal vascular resistance, renin release, and sodium retention, alongside afferent mechano- and chemoreceptor signaling in central sympathetic activation.
Renal denervation delayed hypertension onset and increased sodium excretion in spontaneously hypertensive and DOCA-salt rat models through loss of efferent sympathetic activity.
Denervation attenuated blood pressure in Goldblatt hypertensive rats and coarcted dogs by suppressing systemic sympathetic nervous system activity rather than altering renin activity or sodium excretion, demonstrating an afferent nerve-mediated mechanism.

Structured PICO

Does renal denervation prevent or attenuate hypertension in experimental animals and humans?

Population

Experimental animal models (Okamoto and New Zealand spontaneously hypertensive rat, DOCA-salt-treated rat, Goldblatt hypertension rat, chronic coarctation dog) and humans with essential or renovascular hypertension

Intervention

Renal denervation

Outcome

Development and attenuation of hypertensionsurrogate

This review highlights the mechanistic role of efferent and afferent renal nerves in the pathogenesis of hypertension, providing a rationale for renal denervation.

Discussion

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Implication

Supports preclinical rationale for renal denervation; leaves open translation to human hypertension trials.

Cite This Study

Richard E. Katholi (1983) studied this question.

synapsesocial.com/papers/6a1a75cc9fa30811a0b8a19f https://doi.org/10.1152/ajprenal.1983.245.1.f1

Topics

Hypertension management

View Full Paper

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Renal nerves in the pathogenesis of hypertension in experimental animals and humans

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Renal nerves in the pathogenesis of hypertension in experimental animals and humans

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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