August 1, 1987Canadian Journal of Physiology and Pharmacology
The renal afferent nerves in the pathogenesis of hypertension
Why the study?
Does renal denervation reduce the development and severity of hypertension in experimental animal models?
Population
Experimental models of hypertension including deoxycorticosterone acetate-salt hypertensive rats…
Comparison
Total peripheral renal denervation or selective… vs Intact renal nerves (implied)
Design
Review
Authors
Discussion
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Implication
Renal afferent denervation may attenuate renovascular hypertension in animal models; leaves open etiology-specific effects and clinical translation.
Structured PICO
Does renal denervation reduce the development and severity of hypertension in experimental animal models?
P
Population
Experimental models of hypertension including deoxycorticosterone acetate-salt (DOCA-NaCl) hypertensive rats, spontaneously hypertensive rats (SHR), one-kidney one-clip (1K, 1C) and two-kidney one-clip (2K, 1C) Goldblatt hypertensive rats, and dogs with chronic coarctation hypertension
I
Intervention
Total peripheral renal denervation or selective lesioning of the renal afferent nerves (e.g., by dorsal rhizotomy)
C
Comparator
Intact renal nerves (implied)
O
Outcome
Development and severity of hypertensionsurrogate
Renal afferent nerves play a critical role in the pathogenesis of renovascular hypertension but not in genetic models like the spontaneously hypertensive rat.
Cite This Study
Oparil et al. (1987) studied this question.