Importance of the renal nerves in the pathogenesis of experimental hypertension.
Why the study?
Does interruption of renal sympathetic nerves attenuate hypertension in experimental animal models?
Population
Animal models of experimental hypertension
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Reinforces preclinical rationale for renal denervation; leaves open translation to human hypertension.
Structured PICO
Does interruption of renal sympathetic nerves attenuate hypertension in experimental animal models?
P
Population
Animal models of experimental hypertension (including spontaneously hypertensive rat [SHR], DOCA-NaCl rat, one-kidney one-clip and two-kidney one-clip Goldblatt hypertension in rat, and coarctation hypertension in dog)
I
Intervention
Interruption of the renal sympathetic nerves (renal denervation)
O
Outcome
Development or attenuation of hypertensionsurrogate
This review highlights the critical role of renal sympathetic nerves in the pathogenesis of experimental hypertension, providing a mechanistic rationale for renal denervation.
Cite This Study
Winternitz et al. (1982) studied this question.