Role of prostaglandins and kinins in the renal pressor reflex.

Rats subjected to sinoaortic denervation and chronically instrumented with Doppler flow probes on the right renal artery, superior mesenteric artery, and abdominal aorta and with an occluder on the right renal artery, with inhibition of the renin-angiotensin system (captopril).

Intravenous isotonic saline (6% of body weight over 60 minutes); prostaglandin inhibition (intravenous indomethacin and meclofenamate); kallikrein inhibition (aprotinin); or adenosine inhibition (aminophylline or adenosine deaminase).

Renal pressor reflex response to acute unilateral renal artery stenosis (50% decrease in renal blood flow).surrogate