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November 1, 1999Hypertension

Role of Renal Nerves in the Stimulation of the Renin System by Reduced Renal Arterial Pressure

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Why the study?

Does renal denervation blunt the stimulation of the renin system in a rat model of renal artery stenosis?

Population

Male Sprague-Dawley rats undergoing left renal artery clipping (ID 0.2 mm)

Comparison

Left kidney denervation 4 days prior to clipping vs Sham denervation 4 days prior to clipping

Design

Preclinical

Follow-up

up to 4 days

Authors

CWCharlotte WagnerHuntsman Cancer InstituteMHMarkus HinderNovartis (Switzerland)BKBernhard K. KrämerUniversity of Mannheim

Discussion

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Implication

Supports renal nerve role in renin activation during stenosis; hypothesis-generating in this animal model and leaves open clinical translation.

Structured PICO

Does renal denervation blunt the stimulation of the renin system in a rat model of renal artery stenosis?

P
Population
Male Sprague-Dawley rats undergoing left renal artery clipping (ID 0.2 mm)
I
Intervention
Left kidney denervation 4 days prior to clipping (with or without mibefradil 15 mg/kg/d)
C
Comparator
Sham denervation 4 days prior to clipping
O
Outcome
Plasma renin activity and renin mRNA levels at 1, 2, or 4 days after clippingsurrogate

Renal nerves play a crucial role in the background stimulation of renin secretion and mRNA expression during reduced renal arterial pressure.

Cite This Study

Wagner et al. (1999) studied this question.

synapsesocial.com/papers/6a83fa93b0b8dfdc4c62e76ahttps://doi.org/10.1161/01.hyp.34.5.1101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of renal nerves for the expression of renin in adult rat kidney1994 · 54 citations
  2. 2Pressure-dependent renin release and arterial pressure maintenance in conscious rats1994 · 14 citations
  3. 3Interrelation between baroreceptor and macula densa mechanisms in the control of renin secretion.1993 · 22 citations
  4. 4Flow versus pressure in the control of renin release in conscious dogs1997 · 23 citations
  5. 5T‐type and L‐type calcium channel blockers exert opposite effects on renin secretion and renin gene expression in conscious rats1998 · 36 citations