Role of renal nerves for the expression of renin in adult rat kidney
Population
Adult rats
Comparison
Unilateral renal denervation, with or without… vs Contralateral innervated kidneys and…
Design
Preclinical
Authors
Discussion
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Implication
Neural input regulates basal renin in rats; leaves open translation to human cardiorenal states or hypovolemia.
Structured PICO
P
Population
Adult rats
I
Intervention
Unilateral renal denervation (mechanical and chemical), with or without metoprolol (100 mg/kg/day for 2 days) and hypotensive hemorrhage
C
Comparator
Contralateral innervated kidneys and sham-operated animals
O
Outcome
Expression of renin (quantitated by morphometry of renin-containing areas and preprorenin mRNA content)surrogate
Renal neural input significantly contributes to basal renin expression in adult rats, but is less important for renin gene stimulation during severe blood loss.
Cite This Study
Holmer et al. (1994) studied this question.