Why the study?
Does bilateral renal denervation alter renin synthesis in rats on different sodium diets?
Does bilateral renal denervation alter renin synthesis in rats on different sodium diets?
Activation of renin gene expression during sodium depletion in rats depends on renal nerves, whereas suppression during sodium load is independent of renal nerves.
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Findings from this rat model should not alter clinical practice; leaves open renal nerve dependence of renin activation in human sodium-sensitive hypertension.
Golin et al. (2001) studied this question.
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