Key result
Renal denervation chronically lowered basal arterial pressure compared with sham operation (91 vs 101 mmHg), irrespective of dietary sodium intake in normal rats.
Why the study?
Does renal denervation lower arterial pressure independent of dietary sodium intake in normal rats?
Population
Normal Sprague-Dawley rats (n=31)
Comparison
Renal denervation with varying dietary salt intake vs Intact surgery with varying dietary salt intake
Design
Preclinical
Follow-up
Up to 18 days
Authors
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RDNX lowers AP independent of salt intake in normotensive rats; leaves open relevance to human hypertension or clinical practice.
Does renal denervation lower arterial pressure independent of dietary sodium intake in normal rats?
Absolute Event Rate: 91% vs 101%
Renal denervation chronically lowers basal arterial pressure in normal rats, independent of dietary sodium intake.
Jacob et al. (2003) studied Normal rats (n=31). Renal denervation vs. Sham operation was evaluated on Arterial pressure (AP) under basal conditions (0.4% NaCl). Renal denervation chronically lowered basal arterial pressure compared with sham operation (91 vs 101 mmHg), irrespective of dietary sodium intake in normal rats.
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