Why the study?
Does renal denervation lower mean arterial pressure through the loss of beta1-adrenoceptor mediated renin secretion in normal rats?
Population
Male Sprague-Dawley rats (n=28)
Comparison
Bilateral or unilateral renal denervation… vs Sham surgery (n=9)
Design
Preclinical
Follow-up
11 days
Authors
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RDN's MAP-lowering effect persists despite atenolol in rats; leaves open non-renin mechanisms and human relevance.
Does renal denervation lower mean arterial pressure through the loss of beta1-adrenoceptor mediated renin secretion in normal rats?
The chronic arterial pressure-lowering effect of renal denervation in normal rats is not solely dependent on the loss of neural control of renin release.
Jacob et al. (2005) studied this question.
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