Why the study?
Does altered sodium intake or DOCA administration affect renin gene expression differently in the hypothalamus and kidney of rats?
Population
12-week-old male Wistar rats
Comparison
High or low sodium diet, or deoxycorticosterone… vs Normal sodium diet or sham-treated control rats
Design
Preclinical
Follow-up
Up to 8 weeks
Authors
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Differential hypothalamic-renal renin responses to salt implicate brain RAS in hypertension; leaves open translational relevance.
Does altered sodium intake or DOCA administration affect renin gene expression differently in the hypothalamus and kidney of rats?
Renin gene expression is regulated differently in the rat hypothalamus compared to the kidney, suggesting a role for the brain renin-angiotensin system in sodium-induced hypertension.
Nishimura et al. (1997) studied this question.
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