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August 1, 2000Journal of Hypertension

Regulation by sodium intake of type 1 angiotensin II receptor mRNAs in the kidney of Sabra rats

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Why the study?

Does a high sodium diet regulate the expression of type 1 angiotensin II receptor mRNAs in the kidney of Sabra rats?

Population

Sabra rats, sensitive (SBH/y) or resistant (SBN/y) to DOCA salt-induced hypertension

Comparison

High NaCl diet vs Normal (0.4%) NaCl diet

Design

Preclinical

Authors

CNCarole NiccoInsermHMHélène MartinCentre National de la Recherche ScientifiqueCYChana YagilBen-Gurion University of the Negev

Discussion

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Implication

High-sodium diet suppresses renal AT1 mRNA more in salt-sensitive rats; hypothesis-generating and leaves open human relevance.

Key Points

  • To examine the relationship between dietary sodium sensitivity in hypertension development and the renal expression of type 1 angiotensin II receptor subtypes (AT1A and AT1B).
  • Salt-sensitive (SBH/y) and salt-resistant (SBN/y) Sabra rats were fed either a high (8%) or normal (0.4%) NaCl diet, including an additional high-sodium water-enriched group of SBH/y rats.
  • Quantified AT1A and AT1B mRNA expression across kidney zones using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR).
  • High sodium intake decreased plasma renin activity to a greater degree in SBH/y rats (-95%) than in SBN/y rats (-63%).
  • High sodium downregulated AT1A and AT1B mRNAs in the renal cortex (-28% in SBH/y vs. -20% in SBN/y) and inner stripe (-42% in SBH/y vs. -20% in SBN/y).
  • Supplementing the high-sodium diet with water attenuated the reduction of AT1 receptor mRNAs in the cortex and inner stripe without altering plasma renin activity.

Structured PICO

Does a high sodium diet regulate the expression of type 1 angiotensin II receptor mRNAs in the kidney of Sabra rats?

P
Population
Sabra rats, sensitive (SBH/y) or resistant (SBN/y) to DOCA salt-induced hypertension
I
Intervention
High (8%) NaCl diet (with an additional group of SBH/y rats fed a high sodium diet enriched in water)
C
Comparator
Normal (0.4%) NaCl diet
O
Outcome
Expression of angiotensin II receptor subtype (AT1A and AT1B) mRNAs in the four zones of the kidneyssurrogate

A high sodium diet down-regulates AT1A and AT1B gene expression in specific kidney zones of Sabra rats, with a more pronounced effect in hypertension-sensitive rats.

Cite This Study

Nicco et al. (2000) studied this question.

synapsesocial.com/papers/6a7390bb427d94f6ee71b4d5https://doi.org/10.1097/00004872-200018080-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Regulation of Angiotensin II Receptor Subtypes in Rat Kidney by Low Dietary Sodium1995 · 66 citations
  2. 2Type 1 Angiotensin II Receptor Subtypes in Kidney of Normal and Salt-Sensitive Hypertensive Rats1996 · 8 citations
  3. 3Differential regulation of renal glomerular and preglomerular vascular angiotensin II receptors1996 · 25 citations
  4. 4Expression of type 1 angiotensin II receptor subtypes and angiotensin II-induced calcium mobilization along the rat nephron.1997 · 107 citations
  5. 5Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of salt sensitivity and resistance1996 · 53 citations