Key result
A high salt intake downregulated AT1B mRNA expression but not AT1A mRNA or AT1 receptor density, whereas Ang II infusion downregulated both receptor subtypes and density in the kidney.
Population
Wistar rats
Comparison
High-sodium diet and/or Angiotensin II infusion… vs Normal-sodium diet (0.5%, NSD)
Design
Preclinical, divided into four groups
Follow-up
2 weeks
Authors
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Does not warrant clinical changes in salt or Ang II management; leaves open differential AT1 subtype regulation for future studies.
Angiotensin II infusion downregulates renal AT1 receptors through a negative feedback mechanism, while high salt intake selectively downregulates AT1B mRNA expression.
Wang et al. (1996) studied this question. High-sodium diet and/or Angiotensin II infusion vs. Normal-sodium diet (0.5%) was evaluated on Renal AT1A and AT1B mRNA levels and Ang II receptor density. A high salt intake downregulated AT1B mRNA expression but not AT1A mRNA or AT1 receptor density, whereas Ang II infusion downregulated both receptor subtypes and density in the kidney.
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