Why the study?
Does a low-sodium diet alter the expression and function of ANG II receptor subtypes in renal afferent arterioles in rats compared to a high-sodium diet?
Population
Male, 7-wk-old Wistar-Kyoto rats (n=39)
Comparison
Low-sodium diet (0.08%) for 3 weeks vs High-sodium diet (3.2%) for 3 weeks
Design
Preclinical
Follow-up
3 weeks
Authors
Loading...
Dietary sodium modulates renal ANG II responsiveness in rats; leaves open translation to human afferent arteriolar function or hypertension management.
Does a low-sodium diet alter the expression and function of ANG II receptor subtypes in renal afferent arterioles in rats compared to a high-sodium diet?
Chronic changes in sodium intake cause parallel regulation of AT1 receptor gene expression and protein density in renal afferent arterioles, altering renal vascular reactivity to angiotensin II.
Ruan et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: