Why the study?
Does a low-sodium diet alter the expression and function of ANG II receptor subtypes in renal afferent arterioles in rats compared to a high-sodium diet?
Does a low-sodium diet alter the expression and function of ANG II receptor subtypes in renal afferent arterioles in rats compared to a high-sodium diet?
Chronic changes in sodium intake cause parallel regulation of AT1 receptor gene expression and protein density in renal afferent arterioles, altering renal vascular reactivity to angiotensin II.
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Dietary sodium modulates renal ANG II responsiveness in rats; leaves open translation to human afferent arteriolar function or hypertension management.
Ruan et al. (1997) studied this question.
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