Key result
Sodium restriction significantly downregulated preglomerular vascular ANG II receptor density, whereas glomerular ANG II receptors were unchanged.
Population
Sprague-Dawley rats
Comparison
Low- or high-sodium diet, or infusion with… vs Controls
Design
Preclinical
Follow-up
7 days
Authors
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Sodium intake modulates renal ANG II receptor density in rats independently of infusion; leaves open translation to human RAS-targeted therapies.
Endogenous local renal RAS plays a predominant role in regulating AT1 receptors in preglomerular vessels, which are downregulated by sodium restriction.
Amiri et al. (1996) studied this question. Low- or high-sodium diet or ANG II infusion vs. controls was evaluated on Glomerular and preglomerular vascular ANG II receptor characteristics. Sodium restriction significantly downregulated preglomerular vascular ANG II receptor density, whereas glomerular ANG II receptors were unchanged.