Key result
Denervation of the left kidney increased glomerular angiotensin II receptor density by 50%, and V1-receptor blockade increased it by approximately 100% in rats with aortic constriction.
Population
Sprague-Dawley rats with renovascular hypertension due to aortic constriction, and normotensive control rats
Comparison
Denervation of the left kidney, sympathetic… vs Normotensive control rats or untreated state
Design
Preclinical
Authors
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Suggests cross-talk among pressor systems at renal receptors in experimental hypertension; leaves open human relevance.
The renin-angiotensin system at the receptor level is markedly influenced by the activity of other major pressor systems, including sympathetic activity and arginine-vasopressin.
SAHLGREN et al. (1992) studied Renovascular hypertension. Denervation, sympathetic blockade (guanethidine), or V1-receptor blockade vs. Normotensive controls / baseline was evaluated on Glomerular angiotensin II receptor density. Denervation of the left kidney increased glomerular angiotensin II receptor density by 50%, and V1-receptor blockade increased it by approximately 100% in rats with aortic constriction.
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