Population
20 renin transgenic hypertensive rats [TGR27] and 20 Hannover Sprague-Dawley conscious rats, chronically…
Comparison
Lateral cerebral ventricle administration of… vs LCV infusion of artificial cerebrospinal fluid…
Design
Preclinical
Authors
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Central AT1/V1 antagonism lowers MAP in TGR(mRen2)27 rats; leaves open translation to human hypertension mechanisms or therapy.
Elevated blood pressure in TGR(mRen2)27 rats is partly mediated by increased function of brain angiotensinergic AT1 and vasopressinergic V1 systems.
Szczepańska‐Sadowska et al. (1998) studied this question.
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