The transgenic rat model harboring the mouse renin gene demonstrates significant alterations in the central vasopressin axis and a lack of typical cardiovascular and AVP responses to central angiotensin infusion.
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Blunted central AVP/BP responses in this renin-transgenic model warrant caution against clinical translation; leaves open whether similar RAS dysregulation occurs in human hypertension.
Moriguchi et al. (1994) studied this question.
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