Why the study?
Does AT2 receptor blockade with PD123319 alter the pressor, renal excretory, and vasopressin responses to hypertonic saline in (mRen-2)27 transgenic rats?
Population
Chronically catheterized male (mRen-2)27 transgenic rats (Tg+) and normotensive Sprague-Dawley rats (Tg-)
Comparison
PD123319 intravenous bolus followed by infusion… vs 0.9% NaCl intravenous bolus and infusion prior…
Design
Preclinical
Follow-up
60 minutes
Authors
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AT2 receptors may exert a depressor role in salt-induced pressor responses in this model; leaves open translation to human salt-sensitive hypertension.
Does AT2 receptor blockade with PD123319 alter the pressor, renal excretory, and vasopressin responses to hypertonic saline in (mRen-2)27 transgenic rats?
Angiotensin AT2 receptors appear to play a depressor role in the sodium-induced pressor response in the (mRen-2)27 transgenic rat model of hypertension.
Tatsuya Nishioka (1998) studied this question.
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