Why the study?
Does PVN injection of AT1 receptor ASODN reduce mean arterial pressure in salt-loaded mRen-2 transgenic rats?
Population
Male mRen-2 transgenic [Tg(+)] and Tg(-) rats
Comparison
Paraventricular injection of AT1 receptor… vs PVN injection of scrambled oligodeoxynucleotides…
Design
Preclinical
Follow-up
4 days (salt loading), 20 hours (post-injection)
Authors
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Hypothesis-generating for PVN AT1 receptor targeting in salt-sensitive hypertension models; leaves open any clinical translation.
Does PVN injection of AT1 receptor ASODN reduce mean arterial pressure in salt-loaded mRen-2 transgenic rats?
Paraventricular AT1 receptors play a critical role in mediating salt-sensitive hypertension in mRen-2 transgenic rats.
Li et al. (1996) studied this question.
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