Key result
Bilateral injection of 100 pmol valsartan into the RVLM reduced the elevated mean arterial pressure in Dahl salt-sensitive rats on a high-salt diet by approximately 35 mm Hg.
Population
Dahl salt-sensitive and Dahl salt-resistant rats fed diets containing either 0.3% NaCl or 8% NaCl for 3 weeks
Comparison
Microinjection of AT1R antagonist valsartan or… vs Responses compared between DS and DR rats on…
Design
Preclinical
Follow-up
3 weeks (diet duration)
Authors
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RVLM AT1R findings in DS rats are hypothesis-generating; leaves open translation to human salt-sensitive hypertension.
AT1 receptors in the rostral ventrolateral medulla contribute to salt-dependent hypertension in Dahl salt-sensitive rats.
Ito et al. (2003) studied Salt-dependent hypertension. Microinjection of AT1R antagonist valsartan into the RVLM vs. Low salt diet rats and salt-resistant rats was evaluated on Mean arterial pressure (MAP). Bilateral injection of 100 pmol valsartan into the RVLM reduced the elevated mean arterial pressure in Dahl salt-sensitive rats on a high-salt diet by approximately 35 mm Hg.
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