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January 1, 2002Kidney & Blood Pressure Research

Intrarenal Infusion of Angiotensin-(1–7) Modulates Renal Functional Responses to Exogenous Angiotensin II in the Rat

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Population

Normotensive anesthetized rats (n=68 across multiple experimental groups)

Comparison

Intrarenal infusion of Angiotensin- with or… vs Angiotensin II alone, or baseline measurements

Design

Preclinical

Authors

MBMarcela BürgelováInstitute of Clinical and Experimental MedicineHKHerbert J. KramerUniversity of SienaVTVladimı́r TeplanUniversity of Ostrava

Discussion

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Implication

Highlights potential dissociation of Ang II tubular versus vascular renal effects by Ang-(1-7) in rats; leaves open human relevance.

Structured PICO

P
Population
Normotensive anesthetized rats (n=68 across multiple experimental groups)
I
Intervention
Intrarenal infusion of Angiotensin-(1-7) (50 ng/min) with or without Angiotensin II (6 ng/min) and receptor blockers ([7-D-Ala]-Ang-(1-7) and PD 123319)
C
Comparator
Angiotensin II alone, or baseline measurements
O
Outcome
Renal functional responses including glomerular filtration rate (GFR), renal plasma flow (RPF), and absolute and fractional sodium excretionsurrogate

In normotensive rats, high intrarenal Ang-(1-7) concentration attenuates the tubular sodium reabsorptive effect, but not the vascular effect, of exogenous intrarenal Angiotensin II.

Cite This Study

Bürgelová et al. (2002) studied this question.

synapsesocial.com/papers/6a717e3326a7f98052ddd29dhttps://doi.org/10.1159/000066340
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proximal Tubular Angiotensin II Levels and Renal Functional Responses to AT1Receptor Blockade in Nonclipped Kidneys of Goldblatt Hypertensive Rats1999 · 117 citations
  2. 2Effeet of pentobarbital anesthesia and laparotomy on plasma renin activity in the dog1979 · 13 citations
  3. 3[7-D-ALA]-Angiotensin 1-7 Blocks Renal Actions of Angiotensin 1-7 in the Anesthetized Rat1998 · 55 citations
  4. 4Angiotensin-(1–7) can interact with the rat proximal tubule AT4receptor system1999 · 46 citations
  5. 5Metabolism Alters the Selectivity of Angiotensin-(1-7) Receptor Ligands for Angiotensin Receptors2000 · 48 citations