July 1, 1998Journal of Cardiovascular Pharmacology

7-D-ALA-Angiotensin 1-7 Blocks Renal Actions of Angiotensin 1-7 in the Anesthetized Rat

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Population

Anesthetized rats

Comparison

[7-D-Ala]-Ang 1-7 and/or losartan prior to… vs Exogenous Ang 1-7 alone or Ang II alone

Design

Preclinical

Authors

VVVolker VallonNational Institutes of Health NHNils HeyneUniversitätsklinikum Tübingen KRKerstin RichterHelmholtz Zentrum München

Discussion

Member takes

Implication

Suggests non-AT1 receptor mediation of Ang 1-7 renal effects in rats; leaves open translation to human physiology or therapy.

Structured PICO

Population

Anesthetized rats

Intervention

[7-D-Ala]-Ang 1-7 (5 nmol/kg/min) and/or losartan (10 mg/kg, i.v.) prior to exogenous Ang 1-7 (100 pmol/kg/min, i.a.)

Comparator

Exogenous Ang 1-7 alone or Ang II alone

Outcome

Renal response (glomerular filtration rate, urinary flow rate, urinary sodium excretion) and mean arterial blood pressuresurrogate

The renal response to exogenous Ang 1-7 in anesthetized rats is mediated predominantly by a distinct non-AT1 binding site sensitive to blockade by [7-D-Ala]-Ang 1-7.

Cite This Study

Vallon et al. (1998) studied this question.

synapsesocial.com/papers/6a7c905dcc6f1443deba5aa9 https://doi.org/10.1097/00005344-199807000-00025

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7-D-ALA-Angiotensin 1-7 Blocks Renal Actions of Angiotensin 1-7 in the Anesthetized Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

7-D-ALA-Angiotensin 1-7 Blocks Renal Actions of Angiotensin 1-7 in the Anesthetized Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider