Key result
Peritubular capillary infusion of ANG I or ANG II in anesthetized rats increased proximal tubular reabsorption and enhanced tubuloglomerular feedback, effects not blocked by ACE inhibitors.
Why the study?
Does intrarenally generated angiotensin II influence renal hemodynamics and tubular reabsorption in anesthetized rats?
Population
Anesthetized rats (in vivo micropuncture experiments)
Comparison
Peritubular capillary infusion of angiotensin II… vs Baseline or different infusion rates/antagonists
Design
Preclinical
Authors
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Indicates incomplete intrarenal Ang II effects despite ACE inhibition; leaves open translation to human renal disease.
Does intrarenally generated angiotensin II influence renal hemodynamics and tubular reabsorption in anesthetized rats?
Intrarenal conversion of angiotensin I to angiotensin II influences renal hemodynamics and tubular reabsorption through mechanisms that are not fully blocked by acute ACE inhibition.
Mitchell et al. (1991) studied this question. Peritubular capillary infusion of ANG II or ANG I was evaluated on Renal hemodynamics and tubular reabsorption. Peritubular capillary infusion of ANG I or ANG II in anesthetized rats increased proximal tubular reabsorption and enhanced tubuloglomerular feedback, effects not blocked by ACE inhibitors.
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