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April 1, 1995Hypertension

Differential Regulation of Angiotensin II Receptor Subtypes in Rat Kidney by Low Dietary Sodium

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Why the study?

Does a low-sodium diet regulate the expression of renal mRNA encoding AT1 receptor subtypes in male Wistar rats?

Population

Seven-week-old male Wistar rats (n=18)

Comparison

Low-sodium diet (0.07%) for 14 days vs Normal-sodium diet (0.5%) for 14 days

Design

Preclinical

Follow-up

14 days

Authors

YDYong DuJiangnan UniversityDGDeng‐Fu GuoUniversity of IowaTITadashi InagamiHeart Failure / Cardiomyopathy

Discussion

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Implication

Hypothesis-generating in rats; does not support changes to human sodium recommendations.

Structured PICO

Does a low-sodium diet regulate the expression of renal mRNA encoding AT1 receptor subtypes in male Wistar rats?

P
Population
Seven-week-old male Wistar rats (n=18)
I
Intervention
Low-sodium diet (0.07%) for 14 days
C
Comparator
Normal-sodium diet (0.5%) for 14 days
O
Outcome
Expression of renal mRNA encoding angiotensin II type 1 (AT1) receptor subtypes (AT1A and AT1B)surrogate

Dietary sodium differentially modulates the expression of genes encoding AT1 receptor subtypes in the rat kidney, with low sodium increasing AT1A and decreasing AT1B mRNA expression.

Cite This Study

Du et al. (1995) studied this question.

synapsesocial.com/papers/6a885bae8e586ad1c8a5536bhttps://doi.org/10.1161/01.hyp.25.4.872
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of angiotensin II receptors in rat brain during dietary sodium changes.1994 · 73 citations
  2. 2Decreased perfusion pressure modulates renin and ANG II type 1 receptor gene expression in the rat kidney1993 · 44 citations
  3. 3Characterization of angiotensin II receptor subtypes in human glomeruli and mesangial cells1992 · 69 citations
  4. 4Renal injury from angiotensin II-mediated hypertension.1992 · 545 citations
  5. 5Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes.1988 · 40 citations