Key result
Pretreatment with angiotensin II antagonists, prostaglandin synthetase inhibitors, or propranolol did not alter the constancy of GFR and RBF during decreases in renal arterial pressure in dog kidneys.
Why the study?
Does pretreatment with angiotensin II antagonists, prostaglandin synthetase inhibitors, or beta-blockers affect renal autoregulation of GFR and RBF in dog kidneys?
Population
Dog kidneys in situ
Design
Preclinical
Authors
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No mediation by these systems in canine autoregulation; leaves open their relevance in human kidneys or disease.
Does pretreatment with angiotensin II antagonists, prostaglandin synthetase inhibitors, or beta-blockers affect renal autoregulation of GFR and RBF in dog kidneys?
Angiotensin II, prostaglandins, and intrarenal beta receptors do not appear to mediate renal autoregulation of GFR or total RBF in dog kidneys.
Anderson et al. (1975) studied Renal autoregulation. Angiotensin II antagonist, prostaglandin synthetase inhibitors (indomethacin, meclofenamate), or propranolol was evaluated on Constancy of glomerular filtration rate (GFR) and renal blood flow (RBF) after decreases in renal arterial pressure. Pretreatment with angiotensin II antagonists, prostaglandin synthetase inhibitors, or propranolol did not alter the constancy of GFR and RBF during decreases in renal arterial pressure in dog kidneys.
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