What question did this study set out to answer?

To determine whether intrarenal renin activity is required for the autoregulation of renal plasma flow and glomerular filtration rate when renal perfusion pressure declines.

June 1, 1979AJP Renal Physiology

Intrarenal renin and autoregulation of renal plasma flow and glomerular filtration rate

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Why the study?

Is the renin-angiotensin system necessary for the autoregulation of renal plasma flow or glomerular filtration rate in dogs?

Population

Dogs

Comparison

Deoxycorticosterone acetate plus high sodium… vs Non-DOCA-treated animals

Design

Preclinical

Authors

RMRobert MurrayUniversity of Leeds RMRichard L. MalvinUniversity of Bern

Discussion

Member takes

Implication

RAS appears dispensable for renal autoregulation in this canine model; leaves open its role in human physiology and disease.

Key Points

To determine whether intrarenal renin activity is required for the autoregulation of renal plasma flow and glomerular filtration rate when renal perfusion pressure declines.
Evaluated autoregulation of renal plasma flow (RPF) and glomerular filtration rate (GFR) across reductions in renal artery pressure using two-kidney, one-clamp canine models.
Compared untreated dogs against dogs administered deoxycorticosterone acetate (DOCA; 25 mg/kg) plus a high-sodium diet to suppress renin, both with and without unilateral renal artery clamping.
In non-DOCA dogs, unilateral clamping created a significant difference in renal renin activity (RRA) between clamped (171 ± 37 ng AI·mg⁻¹·h⁻¹) and contralateral kidneys (57 ± 23 ng AI·mg⁻¹·h⁻¹; P = 0.004) without altering relative autoregulation.
DOCA and high-sodium treatment suppressed RRA to 5.4 ng AI·mg⁻¹·h⁻¹ and lowered basal RPF by 22% and GFR by 23%, yet kidneys still successfully autoregulated both RPF and GFR.
Kidney autoregulatory capability exhibited no relationship to renal renin activity or renin secretory rates across experimental groups.

Structured PICO

Is the renin-angiotensin system necessary for the autoregulation of renal plasma flow or glomerular filtration rate in dogs?

Population

Dogs (two-kidney, one-clamp dogs and dogs treated with deoxycorticosterone acetate plus high sodium diets with and without renal arterial clamping)

Intervention

Deoxycorticosterone acetate (DOCA; 25 mg/kg) plus high sodium diets with and without renal arterial clamping

Comparator

Non-DOCA-treated animals

Outcome

Autoregulatory responses of renal plasma flow (RPF) and glomerular filtration rate (GFR) to reductions in renal artery pressure (RAP)surrogate

The renin-angiotensin system is not a necessary component in the autoregulation of renal plasma flow or glomerular filtration rate.

Cite This Study

Murray et al. (1979) studied this question.

synapsesocial.com/papers/6a908494e16d749e8fc9296f https://doi.org/10.1152/ajprenal.1979.236.6.f559

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Intrarenal renin and autoregulation of renal plasma flow and glomerular filtration rate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Intrarenal renin and autoregulation of renal plasma flow and glomerular filtration rate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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