Autoregulatory capacity in renal and mesenteric vasculatures of mineralocorticoid hypertensive dogs

7 conscious dogs, chronically instrumented for measurement of aortic blood pressure and superior mesenteric and left renal artery blood flows, right nephrectomy, with hypertension induced by 5 mg/kg/day DOCA and 1% saline.

Acute control of arterial pressure via gravity reservoir at hypertensive and normotensive values for 15-min periods, with and without pharmacological blockades (hexamethonium, prostaglandin inhibition, histamine/adenosine receptor blockade).

Baseline (neurally intact) vs pharmacological blockade; hypertensive vs normotensive pressure levels.

Autoregulatory capacity in renal and mesenteric vasculatures (measured by blood flow and closed-loop gain).surrogate