Key result
Renin depletion abolishes renal blood flow autoregulation and redistributes perfusion to inner cortical-juxtamedullary compartments.
Authors
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May caution RAS modulation in hypoperfusion; leaves open human translation from canine models.
Brech et al. (2008) studied this question. Renin depletion (via high sodium intake and DOCA) vs. Normal dogs (basal conditions) was evaluated on Renal autoregulation and intrarenal distribution of blood flow. Renin depletion abolished renal autoregulation of blood flow and caused a more pronounced redistribution of intrarenal perfusion from outer to inner cortical-juxtamedullary compartments.
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