Why the study?
Does aortic constriction stimulate renin release and autoregulation of renal blood flow in a non-filtering, non-transporting dog kidney model?
Population
Dog model of a non-filtering, non-transporting kidney
Comparison
Aortic constriction at a suprarenal level to… vs Stop-flow kidney and hypertonic mannitol loading…
Design
Preclinical
Authors
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Supports macula densa-independent renin release in canine models; leaves open mechanisms in intact human kidneys.
Does aortic constriction stimulate renin release and autoregulation of renal blood flow in a non-filtering, non-transporting dog kidney model?
Signals from the tubular receptor (macula densa) are not necessary for stimulation of renin release or autoregulation of renal blood flow.
Sanowski et al. (1977) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: