What question did this study set out to answer?

This research investigates the role of renal vascular mechanisms in renin secretion during various stimuli.

May 1, 1971Circulation Research

Evidence for a Renal Vascular Mechanism in Renin Release: New Observations with Graded Stimulation by Aortic Constriction

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Population

Dogs with nonfiltering kidney models, including conscious and anesthetized animals, some with renal…

Design

Preclinical

Authors

EBE H BlaineEngineering Software Research and Development (United States)JDJames O. DavisUniversity of Alberta

Discussion

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Implication

No immediate clinical implications; leaves open the receptor's role in human renin regulation.

Key Points

This research investigates the role of renal vascular mechanisms in renin secretion during various stimuli.
Created nonfiltering kidney models in dogs through bilateral ureteral ligation and renal ischemia.
Measured renin secretion after hemorrhage and suprarenal aortic constriction using a flowmeter.
Conducted graded aortic constriction tests to assess changes in renin secretion.
Renin secretion increased significantly after 20 ml/kg hemorrhage in unilateral nonfiltering kidneys.
Hemorrhage also raised renin secretion in dogs with adrenalectomy and renal denervation.
Increases in renin occurred with slight blood pressure decreases, suggesting intrinsic receptors for renin release.

Structured PICO

Population

Dogs with nonfiltering kidney models (produced by bilateral ureteral ligation and a two-hour period of renal ischemia), including conscious and anesthetized animals, some with renal denervation and adrenalectomy

Intervention

Hemorrhage (20 ml/kg) and graded suprarenal aortic constriction

Outcome

Plasma renin activity and renin secretionsurrogate

This preclinical study provides evidence for an intrinsic vascular receptor within the kidney that mediates renin release independent of macula densa sodium delivery or major sympathetic/catecholamine input.

Cite This Study

Blaine et al. (1971) studied this question.

synapsesocial.com/papers/6a73a32471f2000f104c9e7f https://doi.org/10.1161/01.res.28.5.ii-118

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Evidence for a Renal Vascular Mechanism in Renin Release: New Observations with Graded Stimulation by Aortic Constriction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Evidence for a Renal Vascular Mechanism in Renin Release: New Observations with Graded Stimulation by Aortic Constriction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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