Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1972Circulation ResearchOpen Access

Mechanisms Regulating Renin Release in Dogs with Thoracic Caval Constriction

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does renal denervation, intrarenal papaverine, or intrarenal propranolol alter renin secretion in dogs with thoracic caval constriction?

Population

Dogs with chronic thoracic caval constriction, including groups with filtering and nonfiltering kidneys.

Comparison

Renal denervation, intrarenal papaverine… vs Pre-intervention baseline (control period).

Design

Preclinical

Follow-up

13 days post-denervation

Authors

RWRobert T. WittyDuke UniversityJDJames O. DavisUniversity of AlbertaRSRobert E. ShadeTexas Biomedical Research Institute

Discussion

Loading...

Member takes

Implication

Does not support clinical renal denervation for renin modulation; extends mechanistic evidence in experimental volume overload but leaves human translation open.

Key Points

  • This research aims to understand how different mechanisms regulate renin release during thoracic caval constriction in dogs.
  • Evaluated renal denervation effects on plasma renin activity over 22 days in dogs with caval constriction.
  • Measured renin secretion before and after papaverine infusion in models of filtering and nonfiltering kidneys.
  • Assessed the response of renin levels to propranolol in filtering and nonfiltering kidney models.
  • Plasma renin activity decreased from 82.1 to 40.8 ng angiotensin/ml after renal denervation (P < 0.001).
  • Papaverine reduced renin secretion from 1090 to 497 ng angiotensin/min (P < 0.005) in the nonfiltering kidney model.
  • Propranolol treatment decreased renin secretion, indicating beta receptor involvement in both kidney models.

Structured PICO

Does renal denervation, intrarenal papaverine, or intrarenal propranolol alter renin secretion in dogs with thoracic caval constriction?

P
Population
Dogs with chronic thoracic caval constriction (a model of chronic ascites), including groups with filtering and nonfiltering kidneys.
I
Intervention
Renal denervation, intrarenal papaverine infusion, or intrarenal propranolol.
C
Comparator
Pre-intervention baseline (control period).
O
Outcome
Plasma renin activity and renin secretion rate.surrogate

This preclinical study demonstrates that renin hypersecretion in chronic caval constriction is mediated by renal nerves, intrarenal vascular receptors, and beta receptors.

Cite This Study

Witty et al. (1972) studied this question.

synapsesocial.com/papers/6a709b045d37378ac1ddba86https://doi.org/10.1161/01.res.31.3.339

Topics

HFrEF treatmentHeart failure
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin Release after Hemorrhage and after Suprarenal Aortic Constriction in Dogs without Sodium Delivery to the Macula Densa1970 · 135 citations
  2. 2Physiology of the Kidney and Body Fluids.1969 · 255 citations