Why the study?
Does renal arterial infusion of sodium or potassium inhibit renin secretion in dogs with thoracic inferior vena caval constriction?
Population
Dogs with thoracic inferior vena caval constriction, utilizing either a nonfiltering or filtering kidney model
Comparison
Renal arterial infusion of hypertonic sodium… vs Baseline control observations and comparison…
Design
Preclinical
Follow-up
1 hour
Authors
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Suggests macula densa-dependent Na/K effects on renin in canine models; leaves open human translation.
Does renal arterial infusion of sodium or potassium inhibit renin secretion in dogs with thoracic inferior vena caval constriction?
Sodium and potassium inhibit renin secretion via a mechanism dependent on a functional macula densa and renal tubular system, rather than a direct effect on juxtaglomerular cells.
Shade et al. (1972) studied this question.
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