Why the study?
Does intra-arterial injection of aldosterone differ from direct renal artery injection in affecting sodium and potassium excretion in adrenalectomized dogs?
Does intra-arterial injection of aldosterone differ from direct renal artery injection in affecting sodium and potassium excretion in adrenalectomized dogs?
The route of aldosterone administration (intra-arterial vs direct renal artery) does not alter the timing or magnitude of its effects on renal sodium and potassium handling in dogs.
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Route-independent aldosterone effects in dogs; leaves open whether delivery site influences human cardiorenal outcomes.
Ganong et al. (1958) studied this question.
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