Key result
Moderate and severe sodium depletion elevated and steepened the aldosterone dose-response curves to angiotensin II, whereas sodium loading diminished responsiveness in male beagle dogs.
Why the study?
Does sodium balance alter the responsiveness of plasma aldosterone concentration to angiotensin II in male beagle dogs?
Does sodium balance alter the responsiveness of plasma aldosterone concentration to angiotensin II in male beagle dogs?
Changes in sodium balance directly modulate the sensitivity of aldosterone secretion to angiotensin II in a canine model, with sodium depletion enhancing and sodium loading diminishing responsiveness.
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Sodium balance modulates aldosterone responsiveness in dogs; leaves open translation to human RAAS disorders.
Nicholls et al. (1978) studied Healthy (animal model). Angiotensin II infusion under varying sodium balance states vs. Normal sodium diet (32 mEq/day) was evaluated on Plasma aldosterone concentration responsiveness to angiotensin II. Moderate and severe sodium depletion elevated and steepened the aldosterone dose-response curves to angiotensin II, whereas sodium loading diminished responsiveness in male beagle dogs.
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